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Muscle, Bone and Neurology clinical trial

Physical activity in people living with hip or knee osteoarthritis

The present study aims at offering an in-depth understanding of motivational processes underlying physically active
and sedentary behaviours in people living with lower limb osteoarthritis (OA). Exercise is a first-line treatment in
managing OA symptoms, such as pain and decreased physical function, while being sedentary has been linked to
worse physical functioning and poor health outcomes. Despite this evidence, only a small to moderate proportion of
this population sustain a sufficiently active lifestyle and this is also the case for patients who have participated in
exercise interventions.
A wide array of factors influencing or corresponding to PA in people with lower limb OA has been identified using both
quantitative and qualitative methodologies. The former mainly report non-modifiable (e.g. demographic, diseaserelated)
factors. The latter have been more illustrative in mapping psychosocial determinants of PA behaviour, such as
personal beliefs about OA, attitudes towards and experiences of exercise, personal goals and general attitudes,
support from health professionals and important others. What is lacking in this work is the link to a theoretical
framework to support the conceptualisation and integration of this information to facilitate the development of effective
behavioural change interventions. Moreover, the psychosocial mechanisms underlying motivation for being physically
active and engaging in sedentary behaviours remain to be better understood.
This study will employ qualitative methods to in-depth explore the motivational processes underlying physically active
and sedentary behaviours in people with lower limb OA in the light of Self-Determination Theory (SDT) of human
motivation. SDT offers a framework for understanding motivation in the context of its social and physical environment
and by linking it to personal meanings of engagement and associated well-being. Thus, in the process of
understanding PA and sedentary behaviours, emphasis will be given on the personal experience of OA and OA
patients’ personal definitions of well-being and ill-being.

Inclusion criteria:
Adult patients with a self-reported physician’s diagnosis of hip or knee OA.
Age of 45 years and above.
Participants will be further purposively recruited primarily on the basis of the frequency of exercising. Duration of OA
diagnosis, gender and age will also be taken into account with the aim of including active and sedentary patients,
recently diagnosed and chronic patients, both genders and a wide age range.

Exclusion criteria:
Co-existence of other forms of arthritis, such as rheumatoid arthritis, fibromyalgia, gout, lupus (self-reported).
Co-existence of medical conditions other that OA that significantly affect the person’s ability to exercise (self-reported).
Individuals will also be excluded if they have been diagnosed with any mental illness that cause significant memory
loss (e.g. Alzheimer’s disease and vascular dementia)(self-reported).

Principal Investigator for this trial: Dr A Abhishek

Research Ethics Committee Reference: 16/WM/0070

Contact us about participating in this study by emailing R& or telephoning 0115 924 9924 Ext. 70076


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